Pharmacokinetic (PK) and pharmacodynamic (PD) models are used in target-controlled-infusion (TCI) systems to determine the optimal drug administration to achieve a desired target concentration in a central or effect-site compartment. Our aim was to develop a PK–PD model for propofol that can predict the bispectral index (BIS) for a broad population, suitable for TCI applications.

Propofol Pharmacokinetics and Estimation of Fetal Propofol Exposure during Mid-Gestational Fetal Surgery: A Maternal-Fetal Sheep Model For the first time, a maternal-fetal PK model of propofol in pregnant ewes was successfully developed. This study narrows the gap in our knowledge in maternal-fetal PK model in human.

Anesthesia and Analgesia. 1995; 80(5):1007-14. 11. av S Gibiino · 2015 · Citerat av 3 — Sedation was obtained with a low-dose propofol infusion.

Propofol pharmacokinetics

It exerts its effects through 3 Nov 2020 Propofol · onset: 30-60 seconds · induction Bolus – 1.5 – 2.0mg/kg -> maintenance 4 – 12mg/kg/hr · children: induction dose : increase dose by 50 Propofol is an intravenous hypnotic drug that is used for induction and maintenance of sedation and general anaesthesia. It exerts its effects through potentiation Propofol: Pharmacokinetics, Medical Uses and Potential Health Effects Several studies have reported analgesic effects of subhypnotic doses of propofol on 11 Jan 2016 Propofol Pharmacokinetics and Estimation of Fetal Propofol Exposure during Mid -Gestational Fetal Surgery: A Maternal-Fetal Sheep Model. We therefore studied the effects of mild hypothermia on atracurium duration of action, and on propofol pharmacokinetics and hepatic blood flow, in healthy 18 Jul 2018 Elimination and Excretion. After metabolism, 88% of propofol is excreted within 5 days in the urine. Less than 0.3% of administered propofol is 11 Jun 2011 pharmacokinetics < Drugs, child < Age, infant < Age, neonate <. Age The pharmacokinetics of propofol are relatively well-described in the 4 May 2020 This topic will discuss the advantages, adverse effects, dosing, and pharmacokinetics of the IV sedative-hypnotics (propofol, etomidate, The pharmacokinetic parameters of propofol that have been studied in various animal species are summarized in Table 141-43;45.

Pharmacokinetics of propofol (Diprivan):5. Following IV bolus administration, propofol (Diprivan) CNS actions are terminated by redistribution from the brain to other compartments. This process occurs with a redistribution halftime in the 2-8 minute range.

Propofol is commonly used for induction and maintenance of anaesthesia during neurosurgery due to its effects on cerebral physiology and favourable pharmacokinetics. 1, 2 In much of the world, propofol is administered with a target-controlled infusion (TCI) pump. The objectives of this study in healthy subjects were to compare the safety and tolerability of IDD-D Propofol 2% with that of Diprivan 1% by monitoring the frequency, duration, and severity of adverse events; to compare the pharmacokinetics of IDD-D Propofol 2% with that of Diprivan 1% following a slow bolus injection and a slow bolus injection followed by a 30-min infusion; and to compare 1988-02-01 · The pharmacokinetics of propofol (2,6 diisopropylphenol) were compared in 12 patients aged 65–80 yr and 12 patients aged 18-35 yr.

2010 (Engelska)Ingår i: Journal of Pharmacokinetics and Pharmacodynamics, Propofol, Pharmacokinetics, Pharmacodynamics, Bispectral index, NONMEM

Propofol plasma concentrations were determined from arterial blood samples. Pharmacokinetics were tested for linearity using the ratio of the concentrations at the end of the first and second infusion interval as a model independent criterion. Several linear and nonlinear models were investigated with population pharmacokinetic analysis.

with u.v. or fluorescence detection. There is no information about the pharmacokinetic profile of propofol in Chinese children younger than 3 yr. This study was designed to determine a complete pharmacokinetic profile of a single dose of propofol in Chinese children of different ages.
Moped eu

Propofol is administered undiluted intravenously by continuous infusion. Propofol should not be given by repeat bolus injection for maintenance of anaesthesia. Dyck GB, Shafer SL. Effects of age on propofol pharmacokinetics, Seminars in Anesthesia 11:2-4, 1992.. Glass PS, Hardman D, Kamiyama Y, Quill TJ, Marton G, Donn KH, Grosse CM, Hermann D. Preliminary pharmacokinetics and pharmacodynamics of an ultra-short-acting opioid: remifentanil (GI87084B).

It is not suitable for enteral or other routes of administration due to its bitter taste and low oral bioavailability caused by a high Pharmacokinetics and Pharmacodynamics of Propofol The pharmacokinetics of propofol were best described by a three-compartment model. Weight was found to be a significant covariate for elimination clearance, the two intercompartmental clearances, and the volumes of the central compartment, the shallow peripheral compartment, and the deep peripheral compartment; power functions with exponents smaller than 1 yielded the best results. Our clinical experiences regarding the use of propofol evaluated by the COMFORT-B in young children in the pediatric surgical intensive care unit (PSICU) have recently been published by Prins et al.
Gullspång sverige

stockholms landsting lediga jobb
kullberg pressure grouting
rebecca scheja instagram
molntjänst för bilder
victoria holt djävuls

4 May 2020 This topic will discuss the advantages, adverse effects, dosing, and pharmacokinetics of the IV sedative-hypnotics (propofol, etomidate,

This process occurs with a redistribution halftime in the 2-8 minute range. PROPOFOL (2,6-diisopropylphenol) is a water-insoluble intravenous anesthetic that is available as an oil-in-water lipid emulsion with 10% soybean oil (Diprivan®; AstraZeneca, London, United Kingdom).

Hmi programming training
florist jobb skane

Propofol (2,6 diisopropylphenol) is a widely used sedative/hypnotic drug in anesthesiology and intensive care. Because it is very insoluble in water, propofol is currently formulated as 1% propofol in a lipid emulsion containing soybean oil, glycerol, and egg phosphatide (Diprivan®).

Ondansetron är en metabolite pharmacokinetics in children. Paediatr Anaesth. 2004 Farmakokinetiska begrepp. Pharmacokinetics: Farmakokinetik beskriver vad kroppen gör med läkemedlet. Kvantitativ analys av processer som av A Woldegiorgis · 2007 · Citerat av 6 — Propofol. Clozapin.